Symbols / GYRE Stock $7.44 -3.75% Gyre Therapeutics, Inc.

Healthcare • Biotechnology • United States • NCM
GYRE (Stock) Chart
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About

Gyre Therapeutics, Inc., a pharmaceutical company, engages in the development and commercialization of small-molecule, anti-inflammatory, and anti-fibrotic drugs targeting organ fibrosis. The company offers ETUARY (Pirfenidone), an anti-fibrotic drug approved for the treatment of idiopathic pulmonary fibrosis; and under Phase 3 trials for the treatment of pneumoconiosis. It is also involved in the development of F351 (Hydronidone), a structural derivative of ETUARY, under Phase 3 trials for the treatment of chronic hepatitis B (CHB)-associated liver fibrosis; and completed Phase 1 trials for the treatment of liver fibrosis associated with metabolic dysfunction-associated steatohepatitis. In addition, the company develops F573 is in Phase 2 clinical trials for the treatment of acute/acute-on-chronic liver failure. Further, its preclinical products include F230 for the treatment of pulmonary arterial hypertension; and F528 to treat chronic obstructive pulmonary disease. Gyre Therapeutics, Inc. was founded in 2002 and is headquartered in San Diego, California. Gyre Therapeutics, Inc. operates as a subsidiary of GNI USA, Inc.

Stock Fundamentals
Scroll to Statements
Market Cap 679.38M Enterprise Value 690.62M Income 5.03M Sales 116.59M Book/sh 1.16 Cash/sh 0.57
Dividend Yield Payout 0.00% Employees 625 IPO P/E 372.00 Forward P/E 124.00
PEG P/S 5.83 P/B 6.41 P/C EV/EBITDA 49.29 EV/Sales 5.92
Quick Ratio 4.58 Current Ratio 5.60 Debt/Eq 0.66 LT Debt/Eq EPS (ttm) 0.02 EPS next Y 0.06
EPS Growth Revenue Growth 33.40% Earnings 2026-05-07 ROA 4.93% ROE 8.21% ROIC
Gross Margin 95.36% Oper. Margin 0.32% Profit Margin 4.31% Shs Outstand 91.31M Shs Float 20.95M Short Float 9.72%
Short Ratio 9.99 Short Interest 52W High 11.78 52W Low 6.57 Beta 6.40 Avg Volume 95.89K
Volume 33.82K Target Price $18.67 Recom None Prev Close $7.73 Price $7.44 Change -3.75%
Valuation Models

Price estimates from analyst targets and simple models.

1. Analyst consensus
$18.67
Mean price target
2. Current target
$7.44
Latest analyst target
3. DCF / Fair value
$0.39
Simplified: (Free Cash Flow ÷ Shares) × 18 (P/FCF multiple). Not a …
Ratings
Current target
$7.44
Low
$18.00
High
$20.00
Mean
$18.67

Latest analyst rating changes

Date Action Analyst Rating Change Price Target
2025-10-10 init Jefferies — → Buy $16
2025-08-26 init HC Wainwright & Co. — → Buy $18
Insider Transactions
Filed Date Insider Relationship Transaction Shares Price Value SEC
2025-05-28 MA SONGJIANG President 2,558 $10.07 $26,179
2025-05-23 MA SONGJIANG President 2,182 $10.24 $23,804
2025-05-21 MA SONGJIANG President 4,000 $10.83 $44,160
2025-05-19 MA SONGJIANG President 4,000 $11.11 $44,840
2025-05-15 MA SONGJIANG President 2,020 $10.68 $21,586
2025-05-13 MA SONGJIANG President 4,000 $10.56 $43,860
2025-04-16 EASTLING THOMAS WILSON Director 15,000 $6.93 $103,950
2025-04-01 YE WEIGUO Chief Operating Officer 50,000 $0.75 $37,500
2025-03-27 YE WEIGUO Chief Operating Officer 650,000 $0.75 $487,500
2025-03-21 MA SONGJIANG President 174 $10.00 $1,740
Financials
Statement View
Amounts in millions (2 decimals, no suffix) • EPS per share (2 decimals) • Trend = period evolution • YoY Growth = previous period %
Line Item Trend 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Total Revenue
116.59
+10.24%
105.76
-6.78%
113.45
+10.91%
102.29
Operating Revenue
116.59
+10.24%
105.76
-6.78%
113.45
+10.91%
102.29
Cost Of Revenue
5.42
+39.44%
3.88
-16.22%
4.64
-3.28%
4.79
Reconciled Cost Of Revenue
5.42
+39.44%
3.88
-16.22%
4.64
-3.28%
4.79
Gross Profit
111.17
+9.13%
101.87
-6.38%
108.81
+11.61%
97.50
Operating Expense
99.68
+16.39%
85.64
-4.42%
89.60
+1.48%
88.29
Research And Development
13.70
+13.92%
12.02
-12.74%
13.78
-17.42%
16.69
Selling General And Administration
85.98
+16.79%
73.62
-2.90%
75.82
+5.88%
71.61
Selling And Marketing Expense
65.18
+13.33%
57.51
-5.96%
61.16
+12.76%
54.24
General And Administrative Expense
20.80
+29.15%
16.11
+9.87%
14.66
-15.59%
17.37
Other Gand A
20.80
+29.15%
16.11
+9.87%
14.66
-15.59%
17.37
Other Operating Expenses
-0.84
Total Expenses
105.10
+17.39%
89.53
-5.00%
94.24
+1.24%
93.09
Operating Income
11.49
-29.19%
16.23
-15.53%
19.21
+108.77%
9.20
Total Operating Income As Reported
11.49
-28.93%
16.16
+124.04%
-67.23
-830.52%
9.20
EBITDA
14.01
-21.36%
17.82
-12.35%
20.33
+96.74%
10.33
Normalized EBITDA
11.31
+5.52%
10.72
-90.76%
116.03
+1023.03%
10.33
Reconciled Depreciation
2.52
+58.69%
1.59
+42.55%
1.11
-1.33%
1.13
EBIT
11.49
-29.19%
16.23
-15.53%
19.21
+108.77%
9.20
Total Unusual Items
2.70
-61.93%
7.10
+107.42%
-95.70
0.00
Total Unusual Items Excluding Goodwill
2.70
-61.93%
7.10
+107.42%
-95.70
0.00
Special Income Charges
-0.00
+93.94%
-0.07
+99.92%
-86.44
0.00
Other Special Charges
83.10
Net Income
5.03
-58.40%
12.09
+113.00%
-92.93
-4137.05%
2.30
Pretax Income
14.44
-37.82%
23.22
+130.17%
-76.97
-917.73%
9.41
Net Non Operating Interest Income Expense
1.75
+12.93%
1.55
+48.18%
1.04
+43.80%
0.73
Interest Expense Non Operating
0.04
Net Interest Income
1.75
+12.93%
1.55
+48.18%
1.04
+43.80%
0.73
Interest Expense
0.04
Interest Income Non Operating
1.75
+12.93%
1.55
+48.18%
1.04
+47.51%
0.71
Interest Income
1.75
+12.93%
1.55
+48.18%
1.04
+47.51%
0.71
Other Income Expense
1.20
-77.99%
5.44
+105.60%
-97.22
-18705.03%
-0.52
Other Non Operating Income Expenses
-1.50
+9.28%
-1.66
-9.29%
-1.52
-193.62%
-0.52
Gain On Sale Of Security
2.71
-62.23%
7.17
+177.39%
-9.26
Gain On Sale Of Business
0.00
+100.00%
-2.71
0.00
Tax Provision
4.56
-14.36%
5.32
-37.52%
8.52
+67.03%
5.10
Tax Rate For Calcs
0.00
+37.80%
0.00
+9.10%
0.00
+0.00%
0.00
Tax Effect Of Unusual Items
0.85
-47.55%
1.63
+108.09%
-20.10
0.00
Net Income Including Noncontrolling Interests
9.88
-44.80%
17.90
+120.94%
-85.48
-2081.46%
4.31
Net Income From Continuing Operation Net Minority Interest
5.03
-58.40%
12.09
+113.00%
-92.93
-4137.05%
2.30
Net Income From Continuing And Discontinued Operation
5.03
-58.40%
12.09
+113.00%
-92.93
-4137.05%
2.30
Net Income Continuous Operations
9.88
-44.80%
17.90
+120.94%
-85.48
-2081.46%
4.31
Minority Interests
-4.85
+16.51%
-5.81
+22.00%
-7.45
-270.43%
-2.01
Normalized Income
3.18
-51.94%
6.61
+138.15%
-17.33
-852.69%
2.30
Net Income Common Stockholders
5.03
-58.40%
12.09
+113.00%
-92.93
-4137.05%
2.30
Diluted EPS
0.02
-60.00%
0.05
+103.55%
-1.41
-4790.77%
0.03
Basic EPS
0.06
-57.14%
0.14
+109.93%
-1.41
-4790.77%
0.03
Basic Average Shares
89.34
+4.99%
85.09
+29.26%
65.83
-14.04%
76.58
Diluted Average Shares
103.18
+0.87%
102.29
+55.39%
65.83
-14.04%
76.58
Diluted NI Availto Com Stockholders
5.03
-58.40%
12.09
+113.00%
-92.93
-4137.05%
2.30
Gain On Sale Of PPE
-0.00
+93.94%
-0.07
+89.49%
-0.63
0.00
Total Other Finance Cost
-1.04
-43.80%
-0.73
Line Item Trend 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Total Assets
166.13
+32.48%
125.41
+7.61%
116.54
+37.50%
84.75
Current Assets
102.37
+58.01%
64.79
+13.22%
57.22
+15.24%
49.65
Cash Cash Equivalents And Short Term Investments
52.42
+96.56%
26.67
-20.41%
33.51
+33.10%
25.18
Cash And Cash Equivalents
37.07
+213.81%
11.81
-64.75%
33.51
+33.10%
25.18
Cash Financial
163.42
Other Short Term Investments
15.36
+3.34%
14.86
0.00
-100.00%
10.60
Receivables
36.95
+26.73%
29.15
+73.13%
16.84
-1.73%
17.14
Accounts Receivable
31.08
+58.65%
19.59
+29.19%
15.16
-3.65%
15.74
Gross Accounts Receivable
31.23
+57.74%
19.80
+30.22%
15.20
-86.13%
109.61
Allowance For Doubtful Accounts Receivable
-0.15
+27.75%
-0.21
-409.76%
-0.04
+95.24%
-0.86
Receivables Adjustments Allowances
-0.04
+66.94%
-0.12
Other Receivables
0.23
-95.57%
5.19
+303.34%
1.29
-84.85%
8.49
Inventory
10.17
+60.50%
6.34
+48.03%
4.28
-30.07%
6.12
Raw Materials
0.97
+22.17%
0.79
-13.60%
0.92
-12.97%
1.06
Work In Process
6.31
+115.33%
2.93
+46.67%
2.00
-45.54%
3.67
Finished Goods
2.89
+10.71%
2.61
+91.50%
1.36
-2.43%
1.40
Prepaid Assets
1.34
+12.53%
1.19
-23.14%
1.55
+310.34%
0.38
Other Current Assets
1.49
+3.69%
1.44
+37.42%
1.04
+23.96%
0.84
Total Non Current Assets
63.76
+5.18%
60.62
+2.19%
59.32
+69.00%
35.10
Net PPE
24.73
-3.77%
25.70
+8.08%
23.78
+29.40%
18.38
Gross PPE
32.31
+3.22%
31.30
+11.61%
28.04
+25.34%
22.37
Accumulated Depreciation
-7.58
-35.31%
-5.60
-31.28%
-4.26
-6.68%
-4.00
Properties
0.00
0.00
0.00
0.00
Land And Improvements
1.49
-4.23%
1.56
Buildings And Improvements
19.57
+3.10%
18.98
+54.45%
12.29
+13.40%
10.84
Machinery Furniture Equipment
10.84
+5.49%
10.28
+39.09%
7.39
+29.97%
5.68
Construction In Progress
0.77
+244.59%
0.22
-97.18%
7.88
+62.34%
4.85
Other Properties
1.13
-37.79%
1.82
+271.78%
0.49
-26.58%
0.67
Leases
0.00
-100.00%
0.33
Goodwill And Other Intangible Assets
6.15
+260.82%
1.71
+0.41%
1.70
-8.51%
1.86
Other Intangible Assets
6.15
+260.82%
1.71
+0.41%
1.70
-8.51%
1.86
Investments And Advances
23.52
-4.28%
24.57
+4.85%
23.43
+216.89%
7.39
Non Current Accounts Receivable
4.72
Non Current Deferred Assets
6.87
+22.32%
5.62
+19.68%
4.70
+15.05%
4.08
Non Current Deferred Taxes Assets
6.87
+22.32%
5.62
+19.68%
4.70
+15.05%
4.08
Non Current Prepaid Assets
21.73
Other Non Current Assets
2.49
-17.76%
3.03
+204.52%
0.99
-70.68%
3.39
Total Liabilities Net Minority Interest
23.85
-11.68%
27.00
-73.68%
102.59
+718.36%
12.54
Current Liabilities
18.29
-6.30%
19.52
-2.65%
20.05
+63.76%
12.24
Payables And Accrued Expenses
17.53
+35.35%
12.95
-32.24%
19.11
+74.73%
10.94
Payables
5.72
+8.27%
5.29
-47.25%
10.02
+107.52%
4.83
Accounts Payable
0.12
+14.81%
0.11
-69.58%
0.35
+190.98%
0.12
Other Payable
2.43
+14.72%
2.12
-34.62%
3.24
+30.32%
2.49
Current Accrued Expenses
11.80
+54.03%
7.66
-15.70%
9.09
+48.81%
6.11
Pensionand Other Post Retirement Benefit Plans Current
0.01
-98.37%
0.74
+13.73%
0.65
+0.31%
0.65
Total Tax Payable
2.94
+3.85%
2.83
-43.98%
5.05
+140.55%
2.10
Income Tax Payable
2.94
+3.85%
2.83
-43.98%
5.05
+140.55%
2.10
Current Debt And Capital Lease Obligation
0.64
-10.80%
0.71
+239.52%
0.21
-57.32%
0.49
Current Capital Lease Obligation
0.64
-10.80%
0.71
+239.52%
0.21
-57.32%
0.49
Current Deferred Liabilities
0.11
-28.85%
0.16
+97.47%
0.08
-52.69%
0.17
Current Deferred Revenue
0.11
-28.85%
0.16
+97.47%
0.08
-52.69%
0.17
Other Current Liabilities
4.96
Total Non Current Liabilities Net Minority Interest
5.56
-25.69%
7.49
-90.93%
82.54
+27975.85%
0.29
Long Term Debt And Capital Lease Obligation
0.30
-65.76%
0.89
+344.72%
0.20
+64.46%
0.12
Long Term Capital Lease Obligation
0.30
-65.76%
0.89
+344.72%
0.20
+64.46%
0.12
Non Current Deferred Liabilities
0.85
-8.19%
0.93
+335.68%
0.21
+80.51%
0.12
Non Current Deferred Revenue
0.85
-8.19%
0.93
+335.68%
0.21
+80.51%
0.12
Other Non Current Liabilities
1.45
+20585.71%
0.01
-85.71%
0.05
-10.91%
0.06
Preferred Securities Outside Stock Equity
0.00
-100.00%
64.53
0.00
Stockholders Equity
106.03
+67.46%
63.32
+500.04%
-15.83
-137.22%
42.52
Common Stock Equity
106.03
+67.46%
63.32
+500.04%
-15.83
-137.22%
42.52
Capital Stock
0.09
+5.81%
0.09
+11.69%
0.08
+20.31%
0.06
Common Stock
0.09
+5.81%
0.09
+11.69%
0.08
+20.31%
0.06
Share Issued
91.31
+5.80%
86.31
+12.68%
76.60
+0.02%
76.58
Ordinary Shares Number
91.31
+5.80%
86.31
+12.68%
76.60
+0.02%
76.58
Additional Paid In Capital
172.05
+26.33%
136.19
+99.75%
68.18
+107.89%
32.80
Retained Earnings
-68.43
+6.84%
-73.45
+14.13%
-85.54
-1256.70%
7.39
Gains Losses Not Affecting Retained Earnings
2.32
+362.87%
0.50
-65.54%
1.45
-35.89%
2.27
Minority Interest
36.25
+3.33%
35.08
+17.82%
29.78
+0.28%
29.70
Other Equity Adjustments
2.32
+362.87%
0.50
-65.54%
1.45
-35.89%
2.27
Total Equity Gross Minority Interest
142.28
+44.59%
98.40
+605.44%
13.95
-80.68%
72.22
Total Capitalization
106.03
+67.46%
63.32
+500.04%
-15.83
-137.22%
42.52
Working Capital
84.08
+85.74%
45.27
+21.78%
37.17
-0.63%
37.41
Invested Capital
106.03
+67.46%
63.32
+500.04%
-15.83
-137.22%
42.52
Total Debt
0.94
-41.24%
1.60
+290.71%
0.41
-33.28%
0.61
Capital Lease Obligations
0.94
-41.24%
1.60
+290.71%
0.41
-33.28%
0.61
Net Tangible Assets
99.88
+62.10%
61.61
+451.56%
-17.53
-143.10%
40.67
Tangible Book Value
99.88
+62.10%
61.61
+451.56%
-17.53
-143.10%
40.67
Available For Sale Securities
23.52
-4.28%
24.57
+4.85%
23.43
+216.89%
7.39
Derivative Product Liabilities
2.96
-47.76%
5.67
-67.72%
17.56
0.00
Dueto Related Parties Current
0.23
+0.00%
0.23
-83.42%
1.37
+1060.17%
0.12
Inventories Adjustments Allowances
-0.06
Investmentin Financial Assets
23.52
-4.28%
24.57
+4.85%
23.43
+216.89%
7.39
Notes Receivable
5.64
+28.93%
4.37
+1024.16%
0.39
-74.44%
1.52
Line Item Trend 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Operating Cash Flow
1.01
+127.74%
-3.64
-114.06%
25.89
+142.50%
10.68
Cash Flow From Continuing Operating Activities
1.01
+127.74%
-3.64
-114.06%
25.89
+142.50%
10.68
Net Income From Continuing Operations
9.88
-44.80%
17.90
+120.94%
-85.48
-2081.46%
4.31
Depreciation Amortization Depletion
2.52
+58.69%
1.59
+42.55%
1.11
-1.33%
1.13
Depreciation
2.52
+58.69%
1.59
+42.55%
1.11
-1.33%
1.13
Amortization Cash Flow
0.47
Depreciation And Amortization
2.52
+58.69%
1.59
+42.55%
1.11
-1.33%
1.13
Amortization Of Intangibles
0.47
Other Non Cash Items
0.77
+224.96%
-0.61
-100.74%
82.79
+36531.42%
0.23
Stock Based Compensation
7.16
+761.25%
0.83
-88.59%
7.28
-45.53%
13.37
Provisionand Write Offof Assets
0.02
Asset Impairment Charge
-0.06
-137.06%
0.17
+378.69%
-0.06
-377.27%
0.02
Deferred Tax
-1.11
-10.68%
-1.00
+13.62%
-1.16
-38.42%
-0.84
Deferred Income Tax
-1.11
-10.68%
-1.00
+13.62%
-1.16
-38.42%
-0.84
Operating Gains Losses
-2.59
+62.10%
-6.83
-148.91%
13.95
+5371.76%
0.26
Gain Loss On Investment Securities
-2.67
+61.49%
-6.93
-174.49%
9.30
Gain Loss On Sale Of PPE
0.00
-93.94%
0.07
-89.49%
0.63
+15600.00%
0.00
Change In Working Capital
-15.55
+0.85%
-15.69
-310.35%
7.46
+195.65%
-7.80
Change In Receivables
-11.95
-28.73%
-9.29
-813.13%
1.30
+116.44%
-7.92
Changes In Account Receivables
-10.81
-105.55%
-5.26
-1944.56%
0.28
+103.60%
-7.92
Change In Inventory
-3.63
-69.75%
-2.14
-222.44%
1.75
+298.75%
-0.88
Change In Prepaid Assets
-0.21
-139.62%
0.52
+734.15%
-0.08
-108.43%
0.97
Change In Payables And Accrued Expense
1.00
+125.11%
-3.99
-178.78%
5.07
+1006.11%
0.46
Change In Accrued Expense
0.95
+163.19%
-1.50
-203.53%
1.45
-24.45%
1.91
Change In Payable
0.06
+102.25%
-2.49
-168.90%
3.62
+348.63%
-1.46
Change In Account Payable
0.01
+105.31%
-0.24
-227.60%
0.19
+271.43%
-0.11
Change In Other Working Capital
0.03
Change In Other Current Liabilities
-0.79
+0.25%
-0.79
-37.91%
-0.57
-34.03%
-0.43
Investing Cash Flow
-0.47
+97.62%
-19.88
-0.63%
-19.76
-43.04%
-13.81
Cash Flow From Continuing Investing Activities
-0.47
+97.62%
-19.88
-0.63%
-19.76
-43.04%
-13.81
Net PPE Purchase And Sale
-1.16
+39.39%
-1.91
+75.63%
-7.85
-57.53%
-4.99
Purchase Of PPE
-1.19
+48.60%
-2.31
+72.82%
-8.52
-70.85%
-4.99
Sale Of PPE
0.03
-92.52%
0.40
-39.61%
0.66
0.00
Capital Expenditure
-1.92
+38.52%
-3.13
+63.57%
-8.59
-71.79%
-5.00
Net Investment Purchase And Sale
1.42
+109.17%
-15.47
+1.68%
-15.73
-110.25%
-7.48
Purchase Of Investment
-14.01
+9.44%
-15.47
+1.68%
-15.73
-110.25%
-7.48
Sale Of Investment
15.43
0.00
0.00
Net Business Purchase And Sale
0.00
+100.00%
-1.69
-141.93%
4.02
+401.88%
-1.33
Purchase Of Business
0.00
+100.00%
-1.69
-7.66%
-1.57
-17.57%
-1.33
Gain Loss On Sale Of Business
0.00
-100.00%
2.71
0.00
Net Intangibles Purchase And Sale
-0.73
+9.84%
-0.81
-1078.26%
-0.07
-430.77%
-0.01
Purchase Of Intangibles
-0.73
+9.84%
-0.81
-1078.26%
-0.07
-430.77%
-0.01
Net Other Investing Changes
-0.12
+98.30%
-7.29
Financing Cash Flow
24.38
+1059.75%
2.10
-15.92%
2.50
0.00
Cash Flow From Continuing Financing Activities
24.38
+1059.75%
2.10
-15.92%
2.50
0.00
Net Issuance Payments Of Debt
-0.47
Repayment Of Debt
-0.47
Long Term Debt Payments
-0.47
Net Long Term Debt Issuance
-0.47
Net Common Stock Issuance
23.51
+2941.27%
0.77
0.00
Cash Dividends Paid
0.00
Proceeds From Stock Option Exercised
2.36
+26.33%
1.86
0.00
Net Other Financing Charges
-1.49
-177.43%
-0.54
Changes In Cash
24.91
+216.30%
-21.42
-348.18%
8.63
+375.17%
-3.14
Effect Of Exchange Rate Changes
0.34
+225.64%
-0.27
+8.39%
-0.30
+84.24%
-1.89
Beginning Cash Position
11.81
-64.75%
33.51
+33.10%
25.18
-16.65%
30.20
End Cash Position
37.07
+213.81%
11.81
-64.75%
33.51
+33.10%
25.18
Free Cash Flow
-0.91
+86.51%
-6.77
-139.11%
17.31
+204.74%
5.68
Income Tax Paid Supplemental Data
5.62
-34.01%
8.52
+34.23%
6.35
Change In Income Tax Payable
0.04
+102.03%
-2.17
-172.13%
3.00
+323.44%
-1.34
Change In Tax Payable
0.04
+102.03%
-2.17
-172.13%
3.00
+323.44%
-1.34
Common Stock Issuance
23.51
+2941.27%
0.77
0.00
Earnings Losses From Equity Investments
0.08
+108.11%
0.04
-97.18%
1.31
+423.51%
0.25
Interest Paid CFF
-0.04
Issuance Of Capital Stock
23.51
+2941.27%
0.77
-69.08%
2.50
0.00
Net Preferred Stock Issuance
0.00
-100.00%
2.50
0.00
Preferred Stock Issuance
0.00
-100.00%
2.50
0.00
Sale Of Business
0.00
-100.00%
5.59
0.00
Taxes Refund Paid
-6.14
SEC Filings

Recent 10-K, 10-Q, 8-K, and Form 4 (insider) filings.

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