Symbols / OKUR Stock $3.16 -5.39% OnKure Therapeutics, Inc.

Healthcare • Biotechnology • United States • NGM
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Stock Fundamentals
Scroll to Statements
Index EQUITY
Sector Healthcare
Industry Biotechnology
CEO Dr. Nicholas A. Saccomano Ph.D.
Exch · Country NGM · United States
Market Cap 127.65M
Enterprise Value -64.05M
Income -58.75M
Sales
FCF (ttm) -24.25M
Book/sh 4.56
Cash/sh 4.76
Employees 45
Insider 10d
IPO Apr 08, 2021
Div forward ($/yr)
Div TTM ($/yr)
Dividend Yield
Ex-Div Date
5Y Avg Yield
Yield vs 5Y Avg
Payout 0.00%
P/E
Forward P/E -1.48
PEG
P/S
P/B 0.69
P/C
EV/EBITDA 1.05
EV/Sales
Quick Ratio 13.41
Current Ratio 13.78
Debt/Eq 0.22
LT Debt/Eq
EPS (ttm) -4.32
EPS next Y -2.13
EPS Growth
Revenue Growth
EPS Gr Q/Q
Rev Gr Q/Q
Earnings (next) 2026-05-05
Earnings (prior) 2026-05-05
ROA -25.77%
ROE -42.73%
ROIC
Gross Margin 0.00%
Oper. Margin 0.00%
Profit Margin 0.00%
Shs Outstand 40.40M
Shs Float 24.23M
Insider Own 10.48%
Instit Own 74.91%
Short Float 0.29%
Short Ratio 0.56
Short Interest 103.37K
52W High 5.38
vs 52W High -41.26%
52W Low 1.90
vs 52W Low 66.32%
Beta
Impl. Vol.
Rel Volume 0.44
Avg Volume 295.93K
Volume 130.97K
Target (mean) $20.20
Tgt Median $17.00
Tgt Low $11.00
Tgt High $30.00
# Analysts 5
Recom Strong_buy
Prev Close $3.34
Price $3.16
Change -5.39%
About

OnKure Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on the discovery and development of precision medicines that target biologically validated drivers of cancers and other diseases. Its lead product candidate includes OKI-219, a selective inhibitor of phosphoinositide 3-kinase alpha (PI3Ka) harboring the H1047R mutation that is in Phase 1 clinical trial for the treatment of solid tumors, including breast cancer. The company was founded in 2011 and is headquartered in Boulder, Colorado.

Valuation Models

Price estimates from analyst targets and simple models.

1. Analyst consensus Mean price target
2. Current target Latest analyst target
3. DCF / Fair value Simplified: (Free Cash Flow ÷ Shares) × 18 (P/FCF multiple). Not a …
Ratings
Current target
$3.16
Low
$11.00
High
$30.00
Mean
$20.20

Latest analyst rating changes

Date Action Analyst Rating Change Price Target
2026-03-16 main HC Wainwright & Co. Buy → Buy $27
2025-08-26 reit HC Wainwright & Co. Buy → Buy $34
2025-03-18 main HC Wainwright & Co. Buy → Buy $34
2025-03-11 main Oppenheimer Outperform → Outperform $30
2025-01-28 init Jones Trading — → Buy $32
2024-12-05 init Leerink Partners — → Outperform $33
2024-11-08 reit HC Wainwright & Co. Buy → Buy $40
2024-10-10 init Oppenheimer — → Outperform $35
Insider Transactions
Filed Date Insider Relationship Transaction Shares Price Value SEC
2026-03-23 SACCOMANO NICHOLAS A. PH.D. Chief Executive Officer 86 $4.16 $357
2026-03-23 LEVERONE JASON A. CPA Chief Financial Officer 301 $4.16 $1,251
2025-12-31 MATHERS EDWARD T. Director 3,911 $0.00 $0
2025-12-31 MANKE ISAAC Director 5,258 $0.00 $0
2025-12-22 SACCOMANO NICHOLAS A. PH.D. Chief Executive Officer 87 $2.97 $258
2025-12-22 LEVERONE JASON A. CPA Chief Financial Officer 302 $2.97 $896
2025-09-30 MATHERS EDWARD T. Director 4,125 $0.00 $0
2025-09-30 MANKE ISAAC Director 5,545 $0.00 $0
2025-09-22 SACCOMANO NICHOLAS A. PH.D. Chief Executive Officer 88 $2.62 $231
2025-09-22 LEVERONE JASON A. CPA Chief Financial Officer 303 $2.62 $795
Financials
Statement View
Amounts in millions (2 decimals, no suffix) • EPS per share (2 decimals) • Trend = period evolution • YoY Growth = previous period %
Line Item Trend 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Total Revenue
0.00
0.00
0.00
0.00
Operating Revenue
0.00
0.00
0.00
0.00
Operating Expense
62.95
+15.75%
54.39
+47.25%
36.93
+24.08%
29.77
Research And Development
48.26
+10.20%
43.80
+36.37%
32.12
+24.18%
25.86
Selling General And Administration
14.69
+38.70%
10.59
+119.78%
4.82
+23.44%
3.90
General And Administrative Expense
14.69
+38.70%
10.59
+119.78%
4.82
+23.44%
3.90
Other Gand A
14.69
+38.70%
10.59
+119.78%
4.82
+23.44%
3.90
Total Expenses
62.95
+15.75%
54.39
+47.25%
36.93
+24.08%
29.77
Operating Income
-62.95
-15.75%
-54.39
-47.25%
-36.93
-24.08%
-29.77
Total Operating Income As Reported
-62.95
-15.75%
-54.39
-47.25%
-36.93
-24.08%
-29.77
EBITDA
-58.68
-13.47%
-51.71
-48.80%
-34.75
-18.29%
-29.38
Normalized EBITDA
-58.68
-13.47%
-51.71
-48.80%
-34.75
-18.29%
-29.38
Reconciled Depreciation
0.83
+25.38%
0.66
+18.21%
0.56
+44.70%
0.39
EBIT
-59.51
-13.63%
-52.37
-48.32%
-35.31
-18.63%
-29.77
Net Income
-59.52
-12.99%
-52.67
-49.17%
-35.31
-19.65%
-29.51
Pretax Income
-59.52
-12.99%
-52.67
-49.17%
-35.31
-19.65%
-29.51
Net Non Operating Interest Income Expense
3.43
+100.41%
1.71
+5.55%
1.62
+538.98%
0.25
Interest Expense Non Operating
0.01
-97.33%
0.30
0.00
Net Interest Income
3.43
+100.41%
1.71
+5.55%
1.62
+538.98%
0.25
Interest Expense
0.01
-97.33%
0.30
0.00
Interest Income Non Operating
3.44
+70.94%
2.01
+24.03%
1.62
+538.98%
0.25
Interest Income
3.44
+70.94%
2.01
+24.03%
1.62
+538.98%
0.25
Tax Rate For Calcs
0.00
0.00
0.00
0.00
Tax Effect Of Unusual Items
0.00
0.00
0.00
0.00
Net Income Including Noncontrolling Interests
-59.52
-12.99%
-52.67
-49.17%
-35.31
-19.65%
-29.51
Net Income From Continuing Operation Net Minority Interest
-59.52
-12.99%
-52.67
-49.17%
-35.31
-19.65%
-29.51
Net Income From Continuing And Discontinued Operation
-59.52
-12.99%
-52.67
-49.17%
-35.31
-19.65%
-29.51
Net Income Continuous Operations
-59.52
-12.99%
-52.67
-49.17%
-35.31
-19.65%
-29.51
Normalized Income
-59.52
-12.99%
-52.67
-49.17%
-35.31
-19.65%
-29.51
Net Income Common Stockholders
-59.52
-12.99%
-52.67
-49.17%
-35.31
-19.65%
-29.51
Diluted EPS
-15.28
-477.23%
-2.65
-19.65%
-2.21
Basic EPS
-15.28
-477.23%
-2.65
-19.65%
-2.21
Basic Average Shares
3.45
-74.16%
13.34
+0.00%
13.34
Diluted Average Shares
3.45
-74.16%
13.34
+0.00%
13.34
Diluted NI Availto Com Stockholders
-59.52
-12.99%
-52.67
-49.17%
-35.31
-19.65%
-29.51
Line Item Trend 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Total Assets
62.12
-45.94%
114.91
+221.56%
35.73
+123.35%
16.00
Current Assets
60.84
-46.16%
113.00
+234.67%
33.77
+147.86%
13.62
Cash Cash Equivalents And Short Term Investments
59.05
-46.69%
110.76
+270.74%
29.88
+158.82%
11.54
Cash And Cash Equivalents
59.05
-46.69%
110.76
+270.74%
29.88
+158.82%
11.54
Prepaid Assets
2.24
-42.37%
3.89
+213.71%
1.24
Other Current Assets
1.79
-20.21%
2.24
+221.20%
0.70
-16.90%
0.84
Total Non Current Assets
1.28
-32.88%
1.90
-3.25%
1.97
-17.17%
2.38
Net PPE
1.00
-44.01%
1.79
-6.02%
1.91
-6.69%
2.05
Gross PPE
2.47
-15.37%
2.91
+13.17%
2.58
+12.20%
2.29
Accumulated Depreciation
-1.46
-30.56%
-1.12
-68.27%
-0.67
-168.15%
-0.25
Properties
0.00
0.00
0.00
0.00
Machinery Furniture Equipment
0.32
-8.31%
0.35
+15.95%
0.30
+68.16%
0.18
Other Properties
1.06
-28.41%
1.48
+24.58%
1.18
+6.47%
1.11
Leases
1.09
+0.00%
1.09
+0.00%
1.09
+8.57%
1.00
Other Non Current Assets
0.27
+150.46%
0.11
+87.93%
0.06
-82.37%
0.33
Total Liabilities Net Minority Interest
5.93
-46.45%
11.08
-91.95%
137.58
+95.37%
70.42
Current Liabilities
5.92
-43.77%
10.53
+44.54%
7.29
+31.45%
5.54
Payables And Accrued Expenses
2.68
-60.72%
6.82
+25.99%
5.41
+37.59%
3.94
Payables
1.43
-51.72%
2.97
-13.14%
3.42
+35.60%
2.52
Accounts Payable
1.43
-51.72%
2.97
-13.14%
3.42
+35.60%
2.52
Current Accrued Expenses
1.25
-67.66%
3.85
+92.94%
2.00
+41.13%
1.42
Pensionand Other Post Retirement Benefit Plans Current
2.69
-15.13%
3.17
+90.80%
1.66
+14.22%
1.46
Current Debt And Capital Lease Obligation
0.55
+2.43%
0.54
+157.69%
0.21
+37.75%
0.15
Current Capital Lease Obligation
0.55
+2.43%
0.54
+157.69%
0.21
+37.75%
0.15
Total Non Current Liabilities Net Minority Interest
0.01
-97.81%
0.55
-99.58%
130.29
+100.83%
64.88
Long Term Debt And Capital Lease Obligation
0.00
-100.00%
0.55
+17.81%
0.47
-4.12%
0.49
Long Term Capital Lease Obligation
0.00
-100.00%
0.55
+17.81%
0.47
-4.12%
0.49
Other Non Current Liabilities
0.01
Preferred Securities Outside Stock Equity
0.00
-100.00%
129.82
+101.63%
64.39
Stockholders Equity
56.18
-45.89%
103.83
+201.95%
-101.84
-87.15%
-54.42
Common Stock Equity
56.18
-45.89%
103.83
+201.95%
-101.84
-87.15%
-54.42
Capital Stock
0.00
+0.00%
0.00
0.00
-100.00%
0.00
Common Stock
0.00
+0.00%
0.00
0.00
-100.00%
0.00
Share Issued
13.67
+2.45%
13.35
+0.06%
13.34
+0.00%
13.34
Ordinary Shares Number
13.67
+2.45%
13.35
+0.06%
13.34
+0.00%
13.34
Additional Paid In Capital
270.42
+4.59%
258.55
+123608.61%
0.21
-92.13%
2.65
Retained Earnings
-214.24
-38.47%
-154.72
-51.61%
-102.05
-78.80%
-57.07
Total Equity Gross Minority Interest
56.18
-45.89%
103.83
+201.95%
-101.84
-87.15%
-54.42
Total Capitalization
56.18
-45.89%
103.83
+201.95%
-101.84
-87.15%
-54.42
Working Capital
54.92
-46.41%
102.47
+286.97%
26.48
+227.69%
8.08
Invested Capital
56.18
-45.89%
103.83
+201.95%
-101.84
-87.15%
-54.42
Total Debt
0.55
-49.40%
1.08
+60.98%
0.67
+5.81%
0.64
Capital Lease Obligations
0.55
-49.40%
1.08
+60.98%
0.67
+5.81%
0.64
Net Tangible Assets
56.18
-45.89%
103.83
+201.95%
-101.84
-87.15%
-54.42
Tangible Book Value
56.18
-45.89%
103.83
+201.95%
-101.84
-87.15%
-54.42
Line Item Trend 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Operating Cash Flow
-51.83
-1.39%
-51.12
-47.97%
-34.55
-28.17%
-26.95
Cash Flow From Continuing Operating Activities
-51.83
-1.39%
-51.12
-47.97%
-34.55
-28.17%
-26.95
Net Income From Continuing Operations
-59.52
-12.99%
-52.67
-49.17%
-35.31
-19.65%
-29.51
Depreciation Amortization Depletion
0.83
+25.38%
0.66
+18.21%
0.56
+44.70%
0.39
Depreciation
0.83
+25.38%
0.66
+18.21%
0.56
+44.70%
0.39
Depreciation And Amortization
0.83
+25.38%
0.66
+18.21%
0.56
+44.70%
0.39
Other Non Cash Items
0.26
Stock Based Compensation
11.63
+156.80%
4.53
+2176.38%
0.20
+314.58%
0.05
Operating Gains Losses
0.01
-88.89%
0.05
Gain Loss On Investment Securities
0.05
Gain Loss On Sale Of PPE
0.01
0.00
Change In Working Capital
-4.78
-20.95%
-3.95
-65966.67%
0.01
-99.72%
2.12
Change In Prepaid Assets
0.29
-87.19%
2.26
+250.70%
-1.50
-350.90%
-0.33
Change In Payables And Accrued Expense
-4.54
+23.32%
-5.93
-446.00%
1.71
-35.36%
2.65
Change In Other Current Liabilities
-0.52
-86.48%
-0.28
-33.81%
-0.21
-8.25%
-0.19
Investing Cash Flow
-0.05
-100.29%
15.87
+6552.44%
-0.25
+78.31%
-1.13
Cash Flow From Continuing Investing Activities
-0.05
-100.29%
15.87
+6552.44%
-0.25
+78.31%
-1.13
Net PPE Purchase And Sale
-0.05
+11.54%
-0.05
+78.86%
-0.25
+78.31%
-1.13
Purchase Of PPE
-0.05
+11.54%
-0.05
+78.86%
-0.25
+78.31%
-1.13
Capital Expenditure
-0.05
+11.54%
-0.05
+78.86%
-0.25
+78.31%
-1.13
Net Investment Purchase And Sale
0.00
-100.00%
15.93
0.00
Sale Of Investment
0.00
-100.00%
15.93
0.00
Financing Cash Flow
0.16
-99.86%
116.13
+118.60%
53.12
+100.74%
26.46
Cash Flow From Continuing Financing Activities
0.16
-99.86%
116.13
+118.60%
53.12
+100.74%
26.46
Net Issuance Payments Of Debt
0.00
-100.00%
6.00
0.00
Issuance Of Debt
0.00
-100.00%
6.00
0.00
Long Term Debt Issuance
0.00
-100.00%
6.00
0.00
Net Long Term Debt Issuance
0.00
-100.00%
6.00
0.00
Net Common Stock Issuance
0.00
-100.00%
58.91
+90526.15%
0.07
-80.88%
0.34
Proceeds From Stock Option Exercised
0.24
0.00
Net Other Financing Charges
-0.08
-100.15%
51.22
+7184.65%
-0.72
+47.42%
-1.38
Changes In Cash
-51.71
-163.93%
80.89
+341.20%
18.33
+1230.27%
-1.62
Beginning Cash Position
110.76
+270.74%
29.88
+158.82%
11.54
-12.32%
13.16
End Cash Position
59.05
-46.69%
110.76
+270.74%
29.88
+158.82%
11.54
Free Cash Flow
-51.87
-1.38%
-51.17
-47.07%
-34.79
-23.87%
-28.09
Interest Paid Supplemental Data
0.00
0.00
0.00
Common Stock Issuance
0.00
-100.00%
58.91
+90526.15%
0.07
-80.88%
0.34
Issuance Of Capital Stock
0.00
-100.00%
58.91
+9.39%
53.85
+93.42%
27.84
Net Preferred Stock Issuance
0.00
-100.00%
53.78
+95.57%
27.50
Preferred Stock Issuance
0.00
-100.00%
53.78
+95.57%
27.50
SEC Filings

Recent 10-K, 10-Q, 8-K, and Form 4 (insider) filings.

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