Symbols / PTGX $103.78 +0.11% Protagonist Therapeutics, Inc.

Healthcare • Biotechnology • United States • NGM
PTGX Chart
About

Protagonist Therapeutics, Inc. operates as a discovery and development company in the United States. It develops Icotyde, a first-in-class investigational targeted oral peptide for the treatment of adults and pediatric patients 12 years of age and older with moderate-to-severe plaque psoriasis; and Rusfertide, a first-in-class investigational injectable mimetic of the natural hormone hepcidin in Phase 3 development for the treatment of the rare blood disorder polycythemia vera. The company is also developing PN-881, a potential best-in-class oral peptide IL-17 antagonist, for the treatment of immune-mediated skin diseases in Phase 1 clinical trials; PN-477 and PN-458, which are development candidates for the treatment of obesity; PN-8047, an orally administered hepcidin functional mimetic small molecule; L-4R alpha antagonist for the treatment of atopic dermatitis and moderate-to-severe asthma; and amylinR-based oral and subcutaneous mono- and poly-agonists for the treatment of obesity. Protagonist Therapeutics, Inc. was incorporated in 2006 and is headquartered in Newark, California.

Fundamentals
Scroll to Statements
Sector Healthcare Industry Biotechnology Market Cap 6.62B
Enterprise Value 6.07B Income -130.15M Sales 46.02M
Book/sh 9.82 Cash/sh 8.89 Dividend Yield —
Payout 0.00% Employees 132 IPO —
P/E — Forward P/E -239.00 PEG —
P/S 143.91 P/B 10.57 P/C —
EV/EBITDA -38.67 EV/Sales 131.80 Quick Ratio 12.59
Current Ratio 12.71 Debt/Eq 1.68 LT Debt/Eq —
EPS (ttm) -2.05 EPS next Y -0.43 EPS Growth —
Revenue Growth -95.60% Earnings 2026-05-06 ROA -13.99%
ROE -20.18% ROIC — Gross Margin 100.00%
Oper. Margin -6.77% Profit Margin -282.83% Shs Outstand 63.81M
Shs Float 51.90M Short Float 15.07% Short Ratio 12.45
Short Interest — 52W High 107.84 52W Low 39.60
Beta 2.11 Avg Volume 813.93K Volume 601.60K
Target Price $112.42 Recom Strong_buy Prev Close $103.67
Price $103.78 Change 0.11%
Valuation Models

Price estimates from analyst targets and simple models.

1. Analyst consensus
$112.42
Mean price target
2. Current target
$103.78
Latest analyst target
3. DCF / Fair value
$29.80
Simplified: (Free Cash Flow ÷ Shares) × 18 (P/FCF multiple). Not a …
Ratings
Current target
$103.78
Low
$97.00
High
$125.00
Mean
$112.42

Latest analyst rating changes

Date Action Analyst Rating Change Price Target
2026-03-19 main Leerink Partners Outperform → Outperform $110
2026-03-19 main JP Morgan Overweight → Overweight $106
2026-03-19 main Citigroup Buy → Buy $125
2026-03-19 main Barclays Overweight → Overweight $119
2026-03-03 main Goldman Sachs Neutral → Neutral $95
2026-02-26 main TD Cowen Buy → Buy $100
2026-02-26 main Barclays Overweight → Overweight $113
2026-02-26 main Citizens Market Outperform → Market Outperform $112
2026-02-02 main Jefferies Buy → Buy $118
2026-01-30 main HC Wainwright & Co. Buy → Buy $117
2026-01-05 main Truist Securities Buy → Buy $110
2025-12-17 main Barclays Overweight → Overweight $108
2025-12-08 main Citigroup Buy → Buy $115
2025-11-10 main Citigroup Buy → Buy $98
2025-11-07 main JP Morgan Overweight → Overweight $81
2025-11-07 main Barclays Overweight → Overweight $88
2025-11-07 main Citizens Market Outperform → Market Outperform $102
2025-10-28 main Truist Securities Buy → Buy $88
2025-10-28 main Wedbush Outperform → Outperform $86
2025-10-28 reit BTIG Buy → Buy $82
News
RSS: Latest PTGX news
Insider Transactions
Filed Date Insider Relationship Transaction Shares Price Value SEC
2026-03-26 SELICK HAROLD E Director — 24,000 $12.88 $309,120
2026-03-26 MOLINA ARTURO MD Officer — 15,000 $8.04 $120,600
2026-03-26 ALI ASIF Chief Financial Officer — 24,765 $12.17 $438,280
2026-03-26 SELICK HAROLD E Director — 24,000 $105.00 $2,520,000
2026-03-26 MOLINA ARTURO MD Officer — 15,000 $104.79 $1,571,850
2026-03-26 ALI ASIF Chief Financial Officer — 24,765 $104.24 $2,581,504
2026-03-25 PATEL DINESH V Chief Executive Officer — 54,700 $8.58 $469,326
2026-03-25 PATEL DINESH V Chief Executive Officer — 54,700 $101.00 $5,524,700
2026-03-23 PATEL DINESH V Chief Executive Officer — 50,000 $0.00 $0
2026-02-17 WILLIAMS LEWIS T Director — 18,000 $10.84 $195,120
Financials
Statement View
Amounts in millions (2 decimals, no suffix) • EPS per share (2 decimals) • Trend = period evolution • YoY Growth = previous period %
Line Item Trend 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Total Revenue
46.02
-89.41%
434.43
+624.06%
60.00
+125.73%
26.58
Operating Revenue
46.02
-89.41%
434.43
+624.06%
60.00
+125.73%
26.58
Operating Expense
204.14
+12.42%
181.59
+18.18%
153.65
-2.72%
157.95
Research And Development
159.29
+15.32%
138.13
+14.95%
120.16
-4.80%
126.22
Selling General And Administration
44.85
+3.20%
43.46
+29.77%
33.49
+5.52%
31.74
General And Administrative Expense
44.85
+3.20%
43.46
+29.77%
33.49
+5.52%
31.74
Other Gand A
44.85
+3.20%
43.46
+29.77%
33.49
+5.52%
31.74
Total Expenses
204.14
+12.42%
181.59
+18.18%
153.65
-2.72%
157.95
Operating Income
-158.13
-162.54%
252.84
+369.98%
-93.65
+28.71%
-131.37
Total Operating Income As Reported
-158.13
-162.54%
252.84
+369.98%
-93.65
+28.71%
-131.37
EBITDA
-156.85
-161.83%
253.67
+373.72%
-92.67
+28.90%
-130.34
Normalized EBITDA
-156.85
-161.83%
253.67
+373.72%
-92.67
+28.90%
-130.34
Reconciled Depreciation
1.28
+54.96%
0.83
-15.46%
0.98
-5.51%
1.03
EBIT
-158.13
-162.54%
252.84
+369.98%
-93.65
+28.71%
-131.37
Total Unusual Items
—
—
—
0.00
Total Unusual Items Excluding Goodwill
—
—
—
0.00
Special Income Charges
—
—
—
0.00
Net Income
-130.15
-147.29%
275.19
+448.54%
-78.95
+38.02%
-127.39
Pretax Income
-129.31
-146.28%
279.41
+453.88%
-78.95
+38.02%
-127.39
Net Non Operating Interest Income Expense
28.79
+9.40%
26.32
+76.63%
14.90
+266.95%
4.06
Interest Expense Non Operating
—
—
—
0.00
Net Interest Income
28.79
+9.40%
26.32
+76.63%
14.90
+266.95%
4.06
Interest Expense
—
—
—
0.00
Interest Income Non Operating
28.79
+9.40%
26.32
+76.63%
14.90
+266.95%
4.06
Interest Income
28.79
+9.40%
26.32
+76.63%
14.90
+266.95%
4.06
Other Income Expense
0.03
-89.20%
0.25
+224.38%
-0.20
-151.25%
-0.08
Other Non Operating Income Expenses
0.03
-89.20%
0.25
+224.38%
-0.20
-151.25%
-0.08
Tax Provision
0.84
-80.14%
4.22
0.00
0.00
Tax Rate For Calcs
0.00
+1300.00%
0.00
0.00
0.00
Tax Effect Of Unusual Items
0.00
0.00
0.00
0.00
Net Income Including Noncontrolling Interests
-130.15
-147.29%
275.19
+448.54%
-78.95
+38.02%
-127.39
Net Income From Continuing Operation Net Minority Interest
-130.15
-147.29%
275.19
+448.54%
-78.95
+38.02%
-127.39
Net Income From Continuing And Discontinued Operation
-130.15
-147.29%
275.19
+448.54%
-78.95
+38.02%
-127.39
Net Income Continuous Operations
-130.15
-147.29%
275.19
+448.54%
-78.95
+38.02%
-127.39
Normalized Income
-130.15
-147.29%
275.19
+448.54%
-78.95
+38.02%
-127.39
Net Income Common Stockholders
-130.15
-147.29%
275.19
+448.54%
-78.95
+38.02%
-127.39
Diluted EPS
-2.05
-148.46%
4.23
+404.32%
-1.39
+46.54%
-2.60
Basic EPS
-2.05
-145.86%
4.47
+421.58%
-1.39
+46.54%
-2.60
Basic Average Shares
63.57
+3.26%
61.57
+8.46%
56.76
+15.74%
49.04
Diluted Average Shares
63.57
-2.31%
65.08
+14.65%
56.76
+15.74%
49.04
Diluted NI Availto Com Stockholders
-130.15
-147.29%
275.19
+448.54%
-78.95
+38.02%
-127.39
Line Item Trend 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Total Assets
668.19
-10.28%
744.73
+108.05%
357.95
+44.38%
247.93
Current Assets
577.57
-2.38%
591.64
+66.39%
355.58
+46.28%
243.08
Cash Cash Equivalents And Short Term Investments
567.36
+35.44%
418.91
+22.63%
341.62
+43.93%
237.35
Cash And Cash Equivalents
128.39
+32.02%
97.25
-47.92%
186.73
+48.50%
125.74
Other Short Term Investments
438.97
+36.47%
321.66
+107.67%
154.89
+38.78%
111.61
Receivables
4.50
-97.33%
168.49
+1530.76%
10.33
+19769.23%
0.05
Other Receivables
0.01
-95.97%
0.25
+226.32%
0.08
+80.95%
0.04
Taxes Receivable
—
—
—
0.00
Accrued Interest Receivable
4.37
+34.64%
3.24
+1166.41%
0.26
—
Prepaid Assets
5.71
+34.83%
4.24
+16.81%
3.63
-36.01%
5.67
Restricted Cash
—
—
—
—
Other Current Assets
—
—
—
0.04
Total Non Current Assets
90.61
-40.81%
153.08
+6348.36%
2.37
-51.06%
4.85
Net PPE
11.69
-7.28%
12.61
+486.64%
2.15
-53.55%
4.63
Gross PPE
20.00
+1.84%
19.64
+134.31%
8.38
-15.15%
9.88
Accumulated Depreciation
-8.31
-18.19%
-7.04
-12.85%
-6.23
-18.65%
-5.25
Properties
0.00
0.00
0.00
0.00
Machinery Furniture Equipment
1.49
+3.04%
1.45
+26.60%
1.14
+4.96%
1.09
Other Properties
15.58
-1.23%
15.77
+151.25%
6.28
-20.32%
7.88
Leases
2.94
+21.12%
2.42
+151.71%
0.96
+5.48%
0.91
Investments And Advances
78.64
-43.93%
140.25
0.00
—
Other Non Current Assets
0.29
+27.56%
0.23
+0.00%
0.23
+0.00%
0.23
Total Liabilities Net Minority Interest
53.48
-22.97%
69.43
+226.36%
21.27
-34.18%
32.32
Current Liabilities
45.44
-4.13%
47.40
+122.80%
21.27
-31.77%
31.18
Payables And Accrued Expenses
20.84
+23.20%
16.92
+26.79%
13.34
-43.52%
23.63
Payables
5.52
+26.18%
4.38
+402.64%
0.87
-78.52%
4.05
Accounts Payable
5.34
+230.59%
1.61
+109.20%
0.77
-78.79%
3.64
Other Payable
0.18
+150.00%
0.07
-25.25%
0.10
-76.14%
0.41
Current Accrued Expenses
15.32
+22.16%
12.54
+0.55%
12.47
-36.27%
19.57
Pensionand Other Post Retirement Benefit Plans Current
12.76
+15.22%
11.08
+63.25%
6.79
+36.62%
4.97
Total Tax Payable
0.00
-100.00%
2.69
0.00
—
Income Tax Payable
0.00
-100.00%
2.69
0.00
—
Current Debt And Capital Lease Obligation
2.28
+347.65%
0.51
-55.30%
1.14
-54.63%
2.52
Current Capital Lease Obligation
2.28
+347.65%
0.51
-55.30%
1.14
-54.63%
2.52
Current Deferred Liabilities
9.55
-49.45%
18.89
+629600.00%
0.00
-95.65%
0.07
Current Deferred Revenue
9.55
-49.45%
18.89
+629600.00%
0.00
-95.65%
0.07
Total Non Current Liabilities Net Minority Interest
8.04
-63.51%
22.03
0.00
-100.00%
1.14
Long Term Debt And Capital Lease Obligation
8.04
-22.36%
10.36
0.00
-100.00%
1.14
Long Term Capital Lease Obligation
8.04
-22.36%
10.36
0.00
-100.00%
1.14
Non Current Deferred Liabilities
0.00
-100.00%
11.68
0.00
—
Stockholders Equity
614.71
-8.97%
675.29
+100.58%
336.68
+56.15%
215.61
Common Stock Equity
614.71
-8.97%
675.29
+100.58%
336.68
+56.15%
215.61
Capital Stock
0.00
+0.00%
0.00
+0.00%
0.00
0.00
Common Stock
0.00
+0.00%
0.00
+0.00%
0.00
0.00
Preferred Stock
0.00
0.00
0.00
0.00
Share Issued
62.58
+2.53%
61.04
+5.76%
57.71
+16.96%
49.34
Ordinary Shares Number
62.58
+2.53%
61.04
+5.76%
57.71
+16.96%
49.34
Additional Paid In Capital
1,084.74
+6.78%
1,015.90
+6.66%
952.49
+26.54%
752.72
Retained Earnings
-470.67
-38.22%
-340.52
+44.69%
-615.71
-14.71%
-536.75
Gains Losses Not Affecting Retained Earnings
0.64
+881.71%
-0.08
+21.90%
-0.10
+70.75%
-0.36
Other Equity Adjustments
0.64
+881.71%
-0.08
+21.90%
-0.10
+70.75%
-0.36
Total Equity Gross Minority Interest
614.71
-8.97%
675.29
+100.58%
336.68
+56.15%
215.61
Total Capitalization
614.71
-8.97%
675.29
+100.58%
336.68
+56.15%
215.61
Working Capital
532.13
-2.23%
544.24
+62.80%
334.30
+57.77%
211.90
Invested Capital
614.71
-8.97%
675.29
+100.58%
336.68
+56.15%
215.61
Total Debt
10.32
-5.00%
10.87
+852.32%
1.14
-68.79%
3.66
Capital Lease Obligations
10.32
-5.00%
10.87
+852.32%
1.14
-68.79%
3.66
Net Tangible Assets
614.71
-8.97%
675.29
+100.58%
336.68
+56.15%
215.61
Tangible Book Value
614.71
-8.97%
675.29
+100.58%
336.68
+56.15%
215.61
Duefrom Related Parties Current
0.12
-99.93%
165.00
+1550.00%
10.00
+99900.00%
0.01
Dueto Related Parties Current
—
—
—
0.07
Investmentin Financial Assets
—
—
—
—
Line Item Trend 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Operating Cash Flow
57.67
-68.68%
184.15
+362.19%
-70.24
+35.05%
-108.14
Cash Flow From Continuing Operating Activities
57.67
-68.68%
184.15
+362.19%
-70.24
+35.05%
-108.14
Net Income From Continuing Operations
-130.15
-147.29%
275.19
+448.54%
-78.95
+38.02%
-127.39
Depreciation Amortization Depletion
1.28
+54.96%
0.83
-15.46%
0.98
-5.51%
1.03
Depreciation
1.28
+54.96%
0.83
-15.46%
0.98
-5.51%
1.03
Depreciation And Amortization
1.28
+54.96%
0.83
-15.46%
0.98
-5.51%
1.03
Other Non Cash Items
1.58
-23.63%
2.07
-18.19%
2.53
+8.31%
2.33
Stock Based Compensation
45.97
+22.42%
37.55
+28.20%
29.29
+21.04%
24.20
Deferred Tax
—
—
—
0.00
Deferred Income Tax
—
—
—
0.00
Gain Loss On Sale Of PPE
—
—
—
—
Change In Working Capital
146.21
+219.25%
-122.61
-528.41%
-19.51
-151.24%
-7.77
Change In Receivables
164.88
+206.37%
-155.00
-1451.55%
-9.99
-335.50%
4.24
Change In Prepaid Assets
-2.36
+37.37%
-3.77
-314.95%
1.75
-53.30%
3.75
Change In Payables And Accrued Expense
5.61
-28.23%
7.82
+191.63%
-8.53
+25.82%
-11.50
Change In Accrued Expense
4.58
+6.69%
4.29
+176.63%
-5.60
+55.98%
-12.71
Change In Payable
1.03
-70.69%
3.53
+220.25%
-2.93
-341.48%
1.22
Change In Account Payable
3.72
+342.16%
0.84
+129.36%
-2.87
-240.24%
2.04
Change In Other Working Capital
-21.02
-168.76%
30.57
—
-1.60
Change In Other Current Liabilities
-0.90
+59.43%
-2.23
+18.85%
-2.74
-3.08%
-2.66
Investing Cash Flow
-49.33
+83.53%
-299.48
-662.86%
-39.26
-142.92%
91.47
Cash Flow From Continuing Investing Activities
-49.33
+83.53%
-299.48
-662.86%
-39.26
-142.92%
91.47
Net PPE Purchase And Sale
-1.59
-17.34%
-1.35
-122.50%
-0.61
+23.40%
-0.80
Purchase Of PPE
-1.59
-17.34%
-1.35
-122.50%
-0.61
+23.40%
-0.80
Capital Expenditure
-1.59
-17.34%
-1.35
-122.50%
-0.61
+23.40%
-0.80
Net Investment Purchase And Sale
-47.74
+83.99%
-298.13
-671.37%
-38.65
-141.89%
92.26
Purchase Of Investment
-546.59
+12.08%
-621.70
-225.42%
-191.04
+11.09%
-214.87
Sale Of Investment
498.84
+54.17%
323.57
+112.32%
152.40
-50.38%
307.14
Financing Cash Flow
22.86
-11.56%
25.85
-84.83%
170.48
+804.96%
18.84
Cash Flow From Continuing Financing Activities
22.86
-11.56%
25.85
-84.83%
170.48
+804.96%
18.84
Net Issuance Payments Of Debt
—
—
—
0.00
Issuance Of Debt
—
—
—
—
Repayment Of Debt
—
—
—
0.00
Long Term Debt Issuance
—
—
—
—
Long Term Debt Payments
—
—
—
0.00
Net Long Term Debt Issuance
—
—
—
0.00
Net Common Stock Issuance
0.00
0.00
-100.00%
132.10
+807.72%
14.55
Proceeds From Stock Option Exercised
23.34
-11.76%
26.45
-32.42%
39.15
+780.08%
4.45
Net Other Financing Charges
-0.48
+20.17%
-0.60
+21.98%
-0.77
-371.78%
-0.16
Changes In Cash
31.20
+134.87%
-89.48
-246.73%
60.98
+2711.57%
2.17
Effect Of Exchange Rate Changes
—
0.00
0.00
+100.00%
-0.09
Beginning Cash Position
97.47
-47.86%
186.95
+48.41%
125.97
+1.68%
123.89
End Cash Position
128.68
+32.01%
97.47
-47.86%
186.95
+48.41%
125.97
Free Cash Flow
56.08
-69.32%
182.80
+358.02%
-70.84
+34.96%
-108.93
Interest Paid Supplemental Data
3.69
+141.44%
1.53
0.00
0.00
Amortization Of Securities
-7.22
+18.61%
-8.88
-94.24%
-4.57
-732.24%
-0.55
Change In Income Tax Payable
-2.69
-200.00%
2.69
0.00
0.00
Change In Tax Payable
-2.69
-200.00%
2.69
0.00
0.00
Common Stock Issuance
0.00
0.00
-100.00%
132.10
+807.72%
14.55
Issuance Of Capital Stock
0.00
0.00
-100.00%
132.10
+807.72%
14.55
SEC Filings

Recent 10-K, 10-Q, 8-K, and Form 4 (insider) filings.

Trades
Date User Broker Pattern Type Position Size Entry Price Trade P&L Status
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