QURE Chart
About

uniQure N.V. develops treatments for patients suffering from rare and other devastating diseases in the United States. The company offers HEMGENIX that allows people living with hemophilia B to produce factor IX, which can lower the risk of bleeding. Its lead product candidate is AMT-130, a gene therapy candidate, which is in Phase I/II clinical study for the treatment of Huntington's disease. The company also develops AMT-260, which is in Phase I/IIa clinical trial for the treatment of mesial temporal lobe epilepsy; AMT-162, which is in Phase I/IIa clinical trial to treat superoxide dismutase enzyme-amyotrophic lateral sclerosis; and AMT-191, an investigational gene therapy candidate which is in phase I/IIa clinical trial for the treatment of fabry disease. It has a licensing agreement with Apic Bio to develop, manufacture, and commercialize intrathecally administered investigational gene therapy for ALS caused by mutations in SOD-1; and development and commercial supply agreement with CLS Bhering. uniQure N.V. was founded in 1998 and is headquartered in Amsterdam, the Netherlands.

Fundamentals
Scroll to Statements
Sector Healthcare Industry Biotechnology Market Cap 1.48B
Enterprise Value 1.33B Income -235.15M Sales 15.75M
Book/sh 3.68 Cash/sh 11.14 Dividend Yield —
Payout 0.00% Employees 209 IPO —
P/E — Forward P/E -7.24 PEG —
P/S 94.04 P/B 6.46 P/C —
EV/EBITDA -8.64 EV/Sales 84.71 Quick Ratio 6.94
Current Ratio 7.12 Debt/Eq 232.43 LT Debt/Eq —
EPS (ttm) -4.40 EPS next Y -3.28 EPS Growth —
Revenue Growth 61.80% Earnings 2026-03-02 ROA -13.89%
ROE -165.27% ROIC — Gross Margin 0.00%
Oper. Margin -13.30% Profit Margin 0.00% Shs Outstand 62.29M
Shs Float 48.99M Short Float 18.51% Short Ratio 6.31
Short Interest — 52W High 71.50 52W Low 7.76
Beta 0.67 Avg Volume 2.26M Volume 586.57K
Target Price $53.12 Recom Buy Prev Close $24.03
Price $23.78 Change -1.04%
Valuation Models

Price estimates from analyst targets and simple models.

1. Analyst consensus
$53.16
Mean price target
2. Current target
$23.82
Latest analyst target
3. DCF / Fair value
$-21.75
Simplified: (Free Cash Flow ÷ Shares) × 18 (P/FCF multiple). Not a …
Ratings
Current target
$23.82
Low
$30.59
High
$96.94
Mean
$53.16

Latest analyst rating changes

Date Action Analyst Rating Change Price Target
2026-02-24 init Wolfe Research — → Peer Perform —
2026-02-10 reit HC Wainwright & Co. Buy → Buy $70
2026-01-28 init Barclays — → Equal-Weight $31
2025-12-11 main Stifel Buy → Buy $40
2025-12-09 main Mizuho Outperform → Outperform $33
2025-12-04 main Chardan Capital Buy → Buy $53
2025-11-12 main Wells Fargo Overweight → Overweight $60
2025-11-11 main Chardan Capital Buy → Buy $53
2025-11-10 main Leerink Partners Outperform → Outperform $60
2025-11-04 main Goldman Sachs Neutral → Neutral $38
2025-11-04 main RBC Capital Outperform → Outperform $45
2025-11-04 down William Blair Outperform → Market Perform —
2025-11-04 main HC Wainwright & Co. Buy → Buy $70
2025-11-03 main Chardan Capital Buy → Buy $53
2025-10-06 main HC Wainwright & Co. Buy → Buy $110
2025-10-02 main Wells Fargo Overweight → Overweight $80
2025-09-25 main Goldman Sachs Neutral → Neutral $56
2025-09-25 main Mizuho Outperform → Outperform $60
2025-09-25 main Wells Fargo Overweight → Overweight $65
2025-09-25 main Guggenheim Buy → Buy $95
Insider Transactions
Date Shares Value Url Text Insider Position Transaction Start Date Ownership
0 25613 630483 — Sale at price 24.39 - 25.09 per share. GUT ROBERT Director — 2026-01-12 00:00:00 D
1 17810 250765 — Conversion of Exercise of derivative security at price 14.08 per share. GUT ROBERT Director — 2026-01-12 00:00:00 D
2 6390 174319 — Sale at price 27.28 per share. KAYE JACK Director — 2026-01-09 00:00:00 D
3 6390 123902 — Conversion of Exercise of derivative security at price 19.39 per share. KAYE JACK Director — 2026-01-09 00:00:00 D
4 31434 856881 — Sale at price 27.22 - 27.30 per share. GUT ROBERT Director — 2025-11-06 00:00:00 D
5 15840 72389 — Conversion of Exercise of derivative security at price 4.57 per share. GUT ROBERT Director — 2025-11-06 00:00:00 D
6 38810 1177517 — Sale at price 30.33 - 30.36 per share. KAYE JACK Director — 2025-11-04 00:00:00 D
7 38810 383535 — Conversion of Exercise of derivative security at price 5.37 - 14.08 per share. KAYE JACK Director — 2025-11-04 00:00:00 D
8 18000 945120 — Sale at price 40.04 - 55.00 per share. KLEMT CHRISTIAN Chief Financial Officer — 2025-09-26 00:00:00 D
9 18000 119640 — Conversion of Exercise of derivative security at price 5.37 - 13.03 per share. KLEMT CHRISTIAN Chief Financial Officer — 2025-09-26 00:00:00 D
Financials
Line Item2024-12-312023-12-312022-12-312021-12-31
TaxEffectOfUnusualItems-2.73M-733.24K298.39K285.16K
TaxRateForCalcs0.260.260.010.01
NormalizedEBITDA-150.16M-250.26M-134.05M318.08M
TotalUnusualItems-10.58M-2.84M26.04M29.50M
TotalUnusualItemsExcludingGoodwill-10.58M-2.84M26.04M29.50M
NetIncomeFromContinuingOperationNetMinorityInterest-239.56M-308.48M-126.79M329.59M
ReconciledDepreciation12.64M11.90M8.54M7.30M
ReconciledCostOfRevenue7.80M3.78M3.34M24.98M
EBITDA-160.75M-253.10M-108.02M347.58M
EBIT-173.39M-265.00M-116.56M340.28M
NetInterestIncome-42.33M-22.00M-11.10M-7.31M
InterestExpense63.74M41.56M11.70M7.47M
InterestIncome21.41M19.56M609.00K162.00K
NormalizedIncome-231.71M-306.37M-152.53M300.37M
NetIncomeFromContinuingAndDiscontinuedOperation-239.56M-308.48M-126.79M329.59M
TotalExpenses209.30M298.33M250.73M212.51M
RentExpenseSupplemental1.36M900.00K820.00K
TotalOperatingIncomeAsReported-184.29M-282.87M-143.16M310.62M
DilutedAverageShares48.65M47.67M46.74M46.84M
BasicAverageShares48.65M47.67M46.74M45.99M
DilutedEPS-4.92-6.47-2.717.04
BasicEPS-4.92-6.47-2.717.17
DilutedNIAvailtoComStockholders-239.56M-308.48M-126.79M329.59M
NetIncomeCommonStockholders-239.56M-308.48M-126.79M329.59M
NetIncome-239.56M-308.48M-126.79M329.59M
NetIncomeIncludingNoncontrollingInterests-239.56M-308.48M-126.79M329.59M
NetIncomeContinuousOperations-239.56M-308.48M-126.79M329.59M
TaxProvision2.43M1.92M-1.47M3.22M
PretaxIncome-237.13M-306.56M-128.26M332.81M
OtherIncomeExpense-12.62M-2.08M27.12M28.62M
OtherNonOperatingIncomeExpenses-2.04M766.00K1.09M-876.00K
SpecialIncomeCharges-73.00K-361.00K0.00
GainOnSaleOfBusiness1.15M0.000.00
RestructuringAndMergernAcquisition1.22M361.00K0.00
GainOnSaleOfSecurity-10.51M-2.48M26.04M29.50M
NetNonOperatingInterestIncomeExpense-42.33M-22.00M-11.10M-7.31M
InterestExpenseNonOperating63.74M41.56M11.70M7.47M
InterestIncomeNonOperating21.41M19.56M609.00K162.00K
OperatingIncome-182.18M-282.49M-144.25M311.49M
OperatingExpense190.97M284.70M247.39M187.53M
OtherOperatingExpenses-5.60M-5.29M-6.08M-12.31M
DepreciationAmortizationDepletionIncomeStatement2.11M2.05M1.18M
DepreciationAndAmortizationInIncomeStatement2.11M2.05M1.18M
DepreciationIncomeStatement2.11M2.05M1.18M
ResearchAndDevelopment143.78M214.86M197.59M143.55M
SellingGeneralAndAdministration50.68M73.08M54.70M56.29M
GeneralAndAdministrativeExpense50.68M73.08M54.70M
OtherGandA16.05M30.39M17.33M
RentAndLandingFees1.36M900.00K820.00K
SalariesAndWages33.27M41.78M36.54M
GrossProfit8.79M2.21M103.14M499.03M
CostOfRevenue18.33M13.63M3.34M24.98M
TotalRevenue27.12M15.84M106.48M524.00M
OperatingRevenue27.12M15.84M106.48M524.00M
Line Item2024-12-312023-12-312022-12-312021-12-31
OrdinarySharesNumber48.99M47.83M46.97M46.30M
ShareIssued48.99M47.83M46.97M46.30M
TotalDebt66.06M138.41M142.89M135.72M
TangibleBookValue-100.21M120.81M391.65M505.46M
InvestedCapital44.57M309.42M578.80M696.74M
WorkingCapital350.24M578.18M400.86M591.48M
NetTangibleAssets-100.21M120.81M391.65M505.46M
CapitalLeaseObligations14.74M36.66M40.10M34.76M
CommonStockEquity-6.75M207.67M476.01M595.78M
TotalCapitalization44.57M309.42M578.80M696.74M
TotalEquityGrossMinorityInterest-6.75M207.67M476.01M595.78M
StockholdersEquity-6.75M207.67M476.01M595.78M
GainsLossesNotAffectingRetainedEarnings-52.80M-53.55M-58.29M-28.86M
OtherEquityAdjustments-52.80M-53.55M-58.29M-28.86M
RetainedEarnings-1.13B-890.41M-581.93M-455.14M
AdditionalPaidInCapital1.17B1.15B1.11B1.08B
CapitalStock2.94M2.88M2.84M2.80M
CommonStock2.94M2.88M2.84M2.80M
TotalLiabilitiesNetMinorityInterest563.29M624.02M228.96M213.40M
TotalNonCurrentLiabilitiesNetMinorityInterest523.24M550.34M153.04M176.64M
OtherNonCurrentLiabilities453.73M412.74M10.27M33.78M
NonCurrentDeferredLiabilities7.04M7.54M8.26M12.91M
NonCurrentDeferredTaxesLiabilities7.04M7.54M8.26M12.91M
LongTermDebtAndCapitalLeaseObligation62.46M130.06M134.51M129.95M
LongTermCapitalLeaseObligation11.14M28.32M31.72M28.99M
LongTermDebt51.32M101.75M102.79M100.96M
CurrentLiabilities40.05M73.67M75.92M36.76M
OtherCurrentLiabilities6.53M29.65M25.98M
CurrentDeferredLiabilities0.00
CurrentDeferredRevenue0.00
CurrentDebtAndCapitalLeaseObligation3.60M8.34M8.38M5.77M
CurrentCapitalLeaseObligation3.60M8.34M8.38M5.77M
PensionandOtherPostRetirementBenefitPlansCurrent12.58M16.26M17.20M12.60M
PayablesAndAccruedExpenses17.34M19.42M24.35M18.39M
CurrentAccruedExpenses10.11M12.83M13.37M15.88M
Payables7.23M6.59M10.98M2.50M
AccountsPayable7.23M6.59M10.98M2.50M
TotalAssets556.54M831.69M704.96M809.18M
TotalNonCurrentAssets166.25M179.84M228.19M180.94M
OtherNonCurrentAssets1.40M3.18M6.06M5.90M
NonCurrentDeferredAssets9.86M12.28M14.53M15.65M
NonCurrentDeferredTaxesAssets9.86M12.28M14.53M15.65M
InvestmentsAndAdvances27.46M2.18M39.98M0.00
OtherInvestments27.46M2.18M
InvestmentinFinancialAssets0.0039.98M0.00
HeldToMaturitySecurities0.0039.98M0.00
GoodwillAndOtherIntangibleAssets93.46M86.86M84.36M90.32M
OtherIntangibleAssets71.04M60.48M58.78M62.69M
Goodwill22.41M26.38M25.58M27.63M
NetPPE34.07M75.34M83.26M69.08M
AccumulatedDepreciation-31.66M-55.67M-44.13M-36.90M
GrossPPE65.73M131.01M127.38M105.98M
Leases24.81M46.51M44.87M45.37M
ConstructionInProgress0.005.67M5.41M5.07M
OtherProperties37.01M72.45M72.12M51.07M
MachineryFurnitureEquipment3.91M6.38M4.99M4.46M
Properties0.000.000.000.00
CurrentAssets390.29M651.85M476.77M628.24M
OtherCurrentAssets7.61M2.65M2.81M2.67M
PrepaidAssets9.28M15.09M11.82M10.54M
Inventory0.0012.02M6.92M0.00
FinishedGoods0.00758.00K1.47M0.00
WorkInProcess0.004.11M1.87M0.00
RawMaterials0.007.16M3.58M0.00
Receivables5.88M4.19M102.38M58.77M
AccountsReceivable5.88M4.19M102.38M58.77M
CashCashEquivalentsAndShortTermInvestments367.52M617.89M352.84M556.26M
OtherShortTermInvestments208.59M376.53M124.83M0.00
CashAndCashEquivalents158.93M241.36M228.01M556.26M
Line Item2024-12-312023-12-312022-12-312021-12-31
FreeCashFlow-194.42M-153.08M-162.75M270.52M
RepaymentOfDebt-53.05M0.000.00-1.57M
IssuanceOfDebt0.000.0064.07M
IssuanceOfCapitalStock2.12M308.00K1.45M33.70M
CapitalExpenditure-11.69M-7.15M-17.69M-17.44M
InterestPaidSupplementalData20.57M16.88M9.25M6.54M
EndCashPosition160.33M244.54M231.17M559.35M
BeginningCashPosition244.54M231.17M559.35M247.68M
EffectOfExchangeRateChanges-4.97M2.27M-1.83M-3.76M
ChangesInCash-79.25M11.11M-326.35M315.43M
FinancingCashFlow-59.49M362.72M1.45M94.86M
CashFlowFromContinuingFinancingActivities-59.49M362.72M1.45M94.86M
NetOtherFinancingCharges-8.56M362.41M-1.33M
ProceedsFromStockOptionExercised2.80M
NetCommonStockIssuance2.12M308.00K1.45M33.70M
CommonStockIssuance2.12M308.00K1.45M33.70M
NetIssuancePaymentsOfDebt-53.05M0.000.0062.49M
NetLongTermDebtIssuance-53.05M0.000.0062.49M
LongTermDebtPayments-53.05M0.000.00-1.57M
LongTermDebtIssuance0.000.0064.07M
InvestingCashFlow162.97M-205.69M-182.73M-67.39M
CashFlowFromContinuingInvestingActivities162.97M-205.69M-182.73M-67.39M
NetInvestmentPurchaseAndSale174.66M-198.53M-163.15M0.00
SaleOfInvestment534.50M167.91M0.000.00
PurchaseOfInvestment-359.84M-366.44M-163.15M0.00
NetBusinessPurchaseAndSale0.000.00-1.90M-49.95M
PurchaseOfBusiness0.000.00-1.90M-49.95M
NetIntangiblesPurchaseAndSale0.000.00
PurchaseOfIntangibles0.000.00
NetPPEPurchaseAndSale-11.69M-7.15M-17.69M-17.44M
PurchaseOfPPE-11.69M-7.15M-17.69M-17.44M
OperatingCashFlow-182.73M-145.93M-145.06M287.96M
CashFlowFromContinuingOperatingActivities-182.73M-145.93M-145.06M287.96M
ChangeInWorkingCapital-3.94M82.44M-43.38M-50.48M
ChangeInPayablesAndAccruedExpense-4.12M-9.50M12.62M8.48M
ChangeInAccruedExpense-5.64M-5.33M3.38M9.20M
ChangeInPayable1.52M-4.17M9.24M-727.00K
ChangeInAccountPayable1.52M-4.17M9.24M-727.00K
ChangeInInventory2.42M-6.74M-6.92M0.00
ChangeInReceivables-2.24M98.68M-49.08M-58.96M
ChangesInAccountReceivables-2.24M-1.32M-4.08M-3.96M
OtherNonCashItems18.93M44.32M5.92M4.04M
StockBasedCompensation22.26M35.09M34.20M25.64M
AmortizationOfSecurities-10.90M-10.92M0.000.00
DeferredTax2.43M1.92M-1.47M3.21M
DeferredIncomeTax2.43M1.92M-1.47M3.21M
DepreciationAmortizationDepletion12.64M11.90M8.54M7.30M
DepreciationAndAmortization12.64M11.90M8.54M7.30M
Depreciation12.64M11.90M8.54M
OperatingGainsLosses15.41M-2.21M-22.08M-31.34M
GainLossOnInvestmentSecurities6.84M
NetForeignCurrencyExchangeGainLoss15.41M-2.21M-22.08M-31.34M
NetIncomeFromContinuingOperations-239.56M-308.48M-126.79M329.59M
SEC Filings

Recent 10-K, 10-Q, 8-K, and Form 4 (insider) filings.

Public Trades for QURE
Date User Asset Broker Type Position Size Entry Price Patterns