Symbols / UPB Stock $9.18 -0.11% Upstream Bio, Inc.

Healthcare • Biotechnology • United States • NMS
UPB (Stock) Chart
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Stock Fundamentals
Scroll to Statements
Index EQUITY
Sector Healthcare
Industry Biotechnology
CEO Dr. E. Rand Sutherland M.D., M.P.H.
Exch · Country NMS · United States
Market Cap 499.58M
Enterprise Value 159.34M
Income -143.44M
Sales 2.85M
FCF (ttm) -88.75M
Book/sh 6.26
Cash/sh 6.28
Employees 75
Insider 10d —
IPO Oct 11, 2024
Div forward ($/yr)
Div TTM ($/yr)
Dividend Yield
Ex-Div Date
5Y Avg Yield
Yield vs 5Y Avg
Payout 0.00%
P/E —
Forward P/E -2.84
PEG —
P/S 175.04
P/B 1.47
P/C —
EV/EBITDA -0.99
EV/Sales 55.83
Quick Ratio 25.56
Current Ratio 26.15
Debt/Eq 0.37
LT Debt/Eq —
EPS (ttm) -2.66
EPS next Y -3.23
EPS Growth —
Revenue Growth 9.00%
EPS Gr Q/Q —
Rev Gr Q/Q —
Earnings (next) 2026-05-05
Earnings (prior) 2026-03-26
ROA -23.99%
ROE -35.44%
ROIC —
Gross Margin 100.00%
Oper. Margin -69.11%
Profit Margin 0.00%
Shs Outstand 54.42M
Shs Float 34.59M
Insider Own 14.88%
Instit Own 98.59%
Short Float 8.56%
Short Ratio 3.73
Short Interest 3.02M
52W High 33.68
vs 52W High -72.74%
52W Low 7.25
vs 52W Low 26.62%
Beta —
Impl. Vol. 6.25%
Rel Volume 0.25
Avg Volume 1.29M
Volume 322.45K
Target (mean) $43.57
Tgt Median $43.00
Tgt Low $15.00
Tgt High $75.00
# Analysts 7
Recom None
Prev Close $9.19
Price $9.18
Change -0.11%
About

Upstream Bio, Inc., a clinical-stage biotechnology company, develops treatments for inflammatory diseases focusing on severe respiratory disorders. It offers verekitug, which is in Phase 2 trials for the treatment of severe asthma and chronic rhinosinusitis with nasal polyps and chronic obstructive pulmonary disease and in Phase I clinical trial for treating chronic obstructive pulmonary disease. The company was incorporated in 2021 and is headquartered in Waltham, Massachusetts.

Valuation Models

Price estimates from analyst targets and simple models.

1. Analyst consensus
$43.57
Mean price target
2. Current target
$9.18
Latest analyst target
3. DCF / Fair value
$-29.36
Simplified: (Free Cash Flow ÷ Shares) × 18 (P/FCF multiple). Not a …
Ratings
Current target
$9.18
Low
$15.00
High
$75.00
Mean
$43.57

Latest analyst rating changes

Date Action Analyst Rating Change Price Target
2026-03-27 down Evercore ISI Group Outperform → In-Line $15
2025-12-18 init Mizuho — → Outperform $51
2025-12-02 init LifeSci Capital — → Outperform $43
2025-11-18 init Evercore ISI Group — → Outperform $40
2025-10-14 init Truist Securities — → Buy $47
2024-11-05 init JP Morgan — → Overweight $38
2024-11-05 init William Blair — → Outperform —
2024-11-05 init TD Cowen — → Buy —
2024-11-05 init Piper Sandler — → Overweight $75
News
RSS: Latest UPB news
Insider Transactions
Filed Date Insider Relationship Transaction Shares Price Value SEC
2026-03-16 GRAY MICHAEL P Chief Operating Officer — 852 $9.29 $7,915
2026-03-16 SUTHERLAND EVERETT RAND Chief Executive Officer — 2,093 $9.29 $19,444
2026-03-16 HOUGHTON ADAM Officer — 699 $9.29 $6,494
2026-03-16 DEYKIN AARON M.D. Officer — 894 $9.29 $8,305
2026-03-16 AMBROSE ALLISON General Counsel — 475 $9.29 $4,413
2026-01-02 GRAY MICHAEL P Chief Operating Officer — 30,500 $0.00 $0
2026-01-02 SUTHERLAND EVERETT RAND Chief Executive Officer — 75,000 $0.00 $0
2026-01-02 HOUGHTON ADAM Officer — 25,000 $0.00 $0
2026-01-02 DEYKIN AARON M.D. Officer — 32,000 $0.00 $0
2026-01-02 AMBROSE ALLISON General Counsel — 17,000 $0.00 $0
Financials
Statement View
Amounts in millions (2 decimals, no suffix) • EPS per share (2 decimals) • Trend = period evolution • YoY Growth = previous period %
Line Item Trend 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Total Revenue
2.85
+20.42%
2.37
-0.42%
2.38
+96.37%
1.21
Operating Revenue
2.85
+20.42%
2.37
-0.42%
2.38
+96.37%
1.21
Operating Expense
163.22
+103.68%
80.13
+88.58%
42.49
+69.16%
25.12
Research And Development
136.81
+117.27%
62.97
+98.01%
31.80
+70.44%
18.66
Selling General And Administration
26.41
+53.83%
17.17
+60.52%
10.70
+65.45%
6.46
General And Administrative Expense
26.41
+53.83%
17.17
+60.52%
10.70
+65.45%
6.46
Salaries And Wages
15.19
+40.08%
10.84
+70.69%
6.35
+70.02%
3.74
Other Gand A
11.22
+77.38%
6.33
+45.66%
4.34
+59.20%
2.73
Total Expenses
163.22
+103.68%
80.13
+88.58%
42.49
+69.16%
25.12
Operating Income
-160.36
-106.21%
-77.76
-93.86%
-40.11
-67.78%
-23.91
Total Operating Income As Reported
-160.36
-106.21%
-77.76
-93.86%
-40.11
-67.78%
-23.91
EBITDA
-160.17
-106.21%
-77.67
-93.93%
-40.05
-67.58%
-23.90
Normalized EBITDA
-160.17
-106.21%
-77.67
-93.93%
-40.05
-67.58%
-23.90
Reconciled Depreciation
0.19
+111.24%
0.09
+48.33%
0.06
+757.14%
0.01
EBIT
-160.36
-106.21%
-77.76
-93.86%
-40.11
-67.78%
-23.91
Net Income
-143.44
-128.39%
-62.81
-205.82%
-20.54
+13.96%
-23.87
Pretax Income
-143.44
-128.39%
-62.81
-205.82%
-20.54
+13.96%
-23.87
Net Non Operating Interest Income Expense
16.93
+39.68%
12.12
+191.07%
4.17
+1931.71%
0.20
Net Interest Income
16.93
+39.68%
12.12
+191.07%
4.17
+1931.71%
0.20
Interest Income Non Operating
16.93
+39.68%
12.12
+191.07%
4.17
+1931.71%
0.20
Interest Income
16.93
+39.68%
12.12
+191.07%
4.17
+1931.71%
0.20
Other Income Expense
-0.01
-100.53%
2.83
-81.61%
15.41
+9497.56%
-0.16
Other Non Operating Income Expenses
-0.01
-100.53%
2.83
-81.61%
15.41
+9497.56%
-0.16
Tax Rate For Calcs
0.00
0.00
0.00
0.00
Tax Effect Of Unusual Items
0.00
0.00
0.00
0.00
Net Income Including Noncontrolling Interests
-143.44
-128.39%
-62.81
-205.82%
-20.54
+13.96%
-23.87
Net Income From Continuing Operation Net Minority Interest
-143.44
-128.39%
-62.81
-205.82%
-20.54
+13.96%
-23.87
Net Income From Continuing And Discontinued Operation
-143.44
-128.39%
-62.81
-205.82%
-20.54
+13.96%
-23.87
Net Income Continuous Operations
-143.44
-128.39%
-62.81
-205.82%
-20.54
+13.96%
-23.87
Normalized Income
-143.44
-128.39%
-62.81
-205.82%
-20.54
+13.96%
-23.87
Net Income Common Stockholders
-143.44
-87.76%
-76.39
-99.70%
-38.26
-60.28%
-23.87
Diluted EPS
-2.66
-127.02%
-1.17
-11.25%
-1.05
-60.28%
-0.66
Basic EPS
-2.66
-127.02%
-1.17
-11.25%
-1.05
-60.28%
-0.66
Basic Average Shares
53.85
+0.47%
53.60
+47.57%
36.32
+0.00%
36.32
Diluted Average Shares
53.85
+0.47%
53.60
+47.57%
36.32
+0.00%
36.32
Diluted NI Availto Com Stockholders
-143.44
-87.76%
-76.39
-99.70%
-38.26
-60.28%
-23.87
Preferred Stock Dividends
—
13.59
-23.30%
17.72
—
Line Item Trend 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Total Assets
353.77
-26.56%
481.72
+311.03%
117.20
+534.26%
18.48
Current Assets
351.80
-26.58%
479.16
+309.55%
117.00
+539.08%
18.31
Cash Cash Equivalents And Short Term Investments
341.51
-27.41%
470.45
+328.42%
109.81
+544.01%
17.05
Cash And Cash Equivalents
101.58
-68.83%
325.89
+1161.53%
25.83
+51.50%
17.05
Other Short Term Investments
239.93
+65.97%
144.56
+72.14%
83.98
0.00
Receivables
2.32
+96.69%
1.18
+400.00%
0.24
-42.72%
0.41
Accounts Receivable
0.67
+8.97%
0.61
+525.51%
0.10
-76.21%
0.41
Accrued Interest Receivable
1.65
+191.53%
0.57
+310.87%
0.14
0.00
Prepaid Assets
7.24
+2.91%
7.04
+6.91%
6.58
+976.92%
0.61
Other Current Assets
0.73
+47.17%
0.49
+33.51%
0.37
+58.80%
0.23
Total Non Current Assets
1.98
-22.82%
2.56
+1166.83%
0.20
+18.13%
0.17
Net PPE
1.78
-24.69%
2.37
+1070.79%
0.20
+23.17%
0.16
Gross PPE
2.12
-15.71%
2.52
+837.17%
0.27
+57.31%
0.17
Accumulated Depreciation
-0.34
-120.51%
-0.16
-132.84%
-0.07
-857.14%
-0.01
Properties
0.00
0.00
0.00
0.00
Machinery Furniture Equipment
0.82
+22.34%
0.67
+235.18%
0.20
+804.55%
0.02
Construction In Progress
—
—
0.00
-100.00%
0.04
Other Properties
1.22
-31.46%
1.78
+4046.51%
0.04
-51.69%
0.09
Leases
0.09
+22.54%
0.07
+162.96%
0.03
+50.00%
0.02
Other Non Current Assets
0.19
+0.00%
0.19
—
0.01
Total Liabilities Net Minority Interest
14.00
+17.98%
11.87
-95.06%
240.32
+92.83%
124.63
Current Liabilities
13.45
+25.29%
10.74
+64.80%
6.51
+34.16%
4.86
Payables And Accrued Expenses
8.54
+16.41%
7.34
+70.53%
4.30
+10.99%
3.88
Payables
2.73
-32.54%
4.04
+103.07%
1.99
+179.49%
0.71
Accounts Payable
2.73
-32.54%
4.04
+103.07%
1.99
+179.49%
0.71
Current Accrued Expenses
5.81
+76.45%
3.29
+42.52%
2.31
-26.93%
3.16
Pensionand Other Post Retirement Benefit Plans Current
4.19
+55.43%
2.70
+24.40%
2.17
+142.78%
0.89
Current Debt And Capital Lease Obligation
0.72
+2.27%
0.70
+1464.44%
0.04
-48.28%
0.09
Current Capital Lease Obligation
0.72
+2.27%
0.70
+1464.44%
0.04
-48.28%
0.09
Total Non Current Liabilities Net Minority Interest
0.55
-51.42%
1.13
-99.52%
233.81
+95.20%
119.78
Long Term Debt And Capital Lease Obligation
0.55
-51.42%
1.13
0.00
-100.00%
0.01
Long Term Capital Lease Obligation
0.55
-51.42%
1.13
0.00
-100.00%
0.01
Preferred Securities Outside Stock Equity
—
0.00
-100.00%
233.81
+95.21%
119.77
Stockholders Equity
339.77
-27.69%
469.85
+481.60%
-123.13
-15.99%
-106.16
Common Stock Equity
339.77
-27.69%
469.85
+481.60%
-123.13
-15.99%
-106.16
Capital Stock
0.05
+1.89%
0.05
+1666.67%
0.00
+0.00%
0.00
Common Stock
0.05
+1.89%
0.05
+1666.67%
0.00
+0.00%
0.00
Preferred Stock
0.00
0.00
0.00
—
Share Issued
54.24
+1.18%
53.60
+4.41%
51.34
+0.00%
51.34
Ordinary Shares Number
54.24
+1.18%
53.60
+4.41%
51.34
+0.00%
51.34
Additional Paid In Capital
673.41
+1.94%
660.60
+13594.11%
4.82
+277.17%
1.28
Retained Earnings
-334.22
-75.19%
-190.78
-49.08%
-127.97
-19.12%
-107.44
Gains Losses Not Affecting Retained Earnings
0.53
+2220.00%
-0.03
-219.05%
0.02
0.00
Other Equity Adjustments
0.53
+2220.00%
-0.03
-219.05%
0.02
—
Total Equity Gross Minority Interest
339.77
-27.69%
469.85
+481.60%
-123.13
-15.99%
-106.16
Total Capitalization
339.77
-27.69%
469.85
+481.60%
-123.13
-15.99%
-106.16
Working Capital
338.35
-27.77%
468.42
+323.99%
110.48
+721.36%
13.45
Invested Capital
339.77
-27.69%
469.85
+481.60%
-123.13
-15.99%
-106.16
Total Debt
1.27
-30.81%
1.83
+3975.56%
0.04
-52.13%
0.09
Capital Lease Obligations
1.27
-30.81%
1.83
+3975.56%
0.04
-52.13%
0.09
Net Tangible Assets
339.77
-27.69%
469.85
+481.60%
-123.13
-15.99%
-106.16
Tangible Book Value
339.77
-27.69%
469.85
+481.60%
-123.13
-15.99%
-106.16
Line Item Trend 2025-12-31 2024-12-31 2023-12-31 2022-12-31
Operating Cash Flow
-133.28
-125.23%
-59.17
-56.02%
-37.93
-99.39%
-19.02
Cash Flow From Continuing Operating Activities
-133.28
-125.23%
-59.17
-56.02%
-37.93
-99.39%
-19.02
Net Income From Continuing Operations
-143.44
-128.39%
-62.81
-205.82%
-20.54
+13.96%
-23.87
Depreciation Amortization Depletion
0.19
+111.24%
0.09
+48.33%
0.06
+757.14%
0.01
Depreciation And Amortization
0.19
+111.24%
0.09
+48.33%
0.06
+757.14%
0.01
Other Non Cash Items
0.56
+120.96%
-2.68
+82.52%
-15.31
-10375.84%
0.15
Stock Based Compensation
10.33
+72.09%
6.00
+75.20%
3.43
+167.94%
1.28
Change In Working Capital
0.59
-68.55%
1.87
+143.51%
-4.30
-226.17%
3.41
Change In Receivables
-0.06
+89.32%
-0.52
-264.01%
0.31
+176.21%
-0.41
Changes In Account Receivables
-0.06
+89.32%
-0.52
-264.01%
0.31
+176.21%
-0.41
Change In Prepaid Assets
-1.52
-51.19%
-1.01
+83.84%
-6.24
-966.15%
-0.58
Change In Payables And Accrued Expense
2.73
-22.56%
3.53
+107.59%
1.70
-62.08%
4.48
Change In Accrued Expense
4.01
+165.48%
1.51
+258.29%
0.42
-89.51%
4.02
Change In Payable
-1.28
-163.51%
2.02
+57.82%
1.28
+176.62%
0.46
Change In Account Payable
-1.28
-163.51%
2.02
+57.82%
1.28
+176.62%
0.46
Change In Other Current Assets
—
—
0.00
+100.00%
-0.01
Change In Other Current Liabilities
-0.56
-324.81%
-0.13
-62.20%
-0.08
-22.39%
-0.07
Investing Cash Flow
-93.48
-57.15%
-59.48
+28.19%
-82.84
-100926.83%
-0.08
Cash Flow From Continuing Investing Activities
-93.48
-57.15%
-59.48
+28.19%
-82.84
-100926.83%
-0.08
Net PPE Purchase And Sale
-0.17
+67.71%
-0.51
-254.86%
-0.14
-75.61%
-0.08
Purchase Of PPE
-0.17
+67.71%
-0.51
-254.86%
-0.14
-75.61%
-0.08
Capital Expenditure
-0.17
+67.71%
-0.51
-254.86%
-0.14
-75.61%
-0.08
Net Investment Purchase And Sale
-93.31
-58.23%
-58.97
+28.69%
-82.70
0.00
Purchase Of Investment
-385.88
-32.78%
-290.61
-125.30%
-128.99
0.00
Sale Of Investment
292.56
+26.30%
231.63
+400.38%
46.29
0.00
Financing Cash Flow
2.44
-99.42%
418.91
+223.36%
129.55
+1200.31%
9.96
Cash Flow From Continuing Financing Activities
2.44
-99.42%
418.91
+223.36%
129.55
+1200.31%
9.96
Net Common Stock Issuance
0.00
-100.00%
272.72
0.00
—
Proceeds From Stock Option Exercised
2.48
+1456.60%
0.16
+34.75%
0.12
0.00
Net Other Financing Charges
-0.03
+99.13%
-3.90
—
-0.04
Changes In Cash
-224.31
-174.71%
300.25
+3318.96%
8.78
+196.08%
-9.14
Beginning Cash Position
326.09
+1162.28%
25.83
+51.50%
17.05
-34.90%
26.19
End Cash Position
101.77
-68.79%
326.09
+1162.28%
25.83
+51.50%
17.05
Free Cash Flow
-133.44
-123.58%
-59.68
-56.77%
-38.07
-99.29%
-19.10
Amortization Of Securities
-1.50
+9.24%
-1.66
-31.35%
-1.26
0.00
Common Stock Issuance
0.00
-100.00%
272.72
0.00
—
Issuance Of Capital Stock
0.00
-100.00%
422.65
+226.54%
129.43
+1194.32%
10.00
Net Preferred Stock Issuance
0.00
-100.00%
149.92
+15.83%
129.43
+1194.32%
10.00
Preferred Stock Issuance
0.00
-100.00%
149.92
+15.83%
129.43
+1194.32%
10.00
SEC Filings

Recent 10-K, 10-Q, 8-K, and Form 4 (insider) filings.

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